The C-terminus of Utp4, mutated in childhood cirrhosis, is essential for ribosome biogenesis
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چکیده
منابع مشابه
The C-terminus of Utp4, mutated in childhood cirrhosis, is essential for ribosome biogenesis
The small subunit (SSU) processome is a large ribonucleoprotein that is required for maturation of the 18S rRNA of the ribosome. Recently, a missense mutation in the C-terminus of an SSU processome protein, Utp4/Cirhin, was reported to cause North American Indian childhood cirrhosis (NAIC). In this study, we use Saccharomyces cerevisiae as a model to investigate the role of the NAIC mutation in...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2010
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkq185